KPV Peptide (10MG) For Sale

What is KPV?

KPV is a tripeptide (lysine-proline-valine) corresponding to positions 11-13 of α-melanocyte-stimulating hormone (α-MSH), a member of the melanocortin peptide family derived from the pro-opiomelanocortin (POMC) precursor protein. Despite being only three amino acids long—representing the COOH-terminal fragment of the full 13-amino acid α-MSH molecule—KPV retains the potent anti-inflammatory and antipyretic signaling activity associated with the complete peptide. This remarkable functional preservation in such a compact structure has made KPV a valuable research tool for investigating melanocortin biology, particularly in the context of immune regulation. Prior research established that KPV can modulate inflammatory responses in multiple systems, making it especially relevant for studying how the brain’s resident immune cells—microglia—regulate their inflammatory output. The peptide’s small size, stability, and preserved bioactivity position it as a tractable model for understanding the endogenous mechanisms that balance immune activation and inflammatory control in both peripheral and central nervous system contexts.

KPV Peptide Information

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